David Moore is a professor of Molecular and Cellular Biology and Human Genetics at Baylor College of Medicine, where he studies the functions of members of the nuclear hormone receptor superfamily. This superfamily includes the well-known steroid and thyroid hormone receptors, along with a number of other proteins whose function is not known.
Moore's work has identified compounds that regulate the activity of several of the newer members of this family and elucidated their function. These studies have revealed that one of these new receptors, called CAR, functions in a chemical defense response that protects the body from potentially toxic foreign compounds, and may also be involved in the management of endogenous toxic products.
“We think most people would be surprised to hear that chronic jet lag was sufficient to induce liver cancer.” –David Moore
Moore has also characterized the functions of two other receptors, FXR and SHP, in cholesterol metabolism and identified a natural product that lowers LDL cholesterol levels as a specific FXR antagonist.
Moore’s research has also linked disruption in circadian rhythm to liver cancer in mice. “This experiment allowed us to take several threads that were already there and put them together to come to this conclusion,” said Moore in an interview with Daily Mail. “We think most people would be surprised to hear that chronic jet lag was sufficient to induce liver cancer.”
Moore is an associate editor of the science journal Endocrinology and a recipient of the Michael E. DeBakey, M.D., Excellence in Research Award.