Mitochondrial Support for Metabolic Aging

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Power up the powerhouse of your cells. Signal is designed to target metabolic aging by protecting mitochondria—where the energy in your cells is made. Increase NAD+ with the precursor NMN to support energy production and activate SIRT3, a key mitochondrial enzyme, to protect and generate new mitochondria and help your cells adapt to daily metabolic changes as you age.

  • Increase levels of the critical coenzyme NAD+ by 40% via the highly efficient precursor NMN
  • Activate sirtuin 3 (SIRT3) to protect and generate new mitochondria to support cellular metabolism and energy
  • Help maintain healthy insulin sensitivity in muscle—essential to maintaining blood sugar levels
  • Support vascular health—critical for your athletic endurance 
  • Support brown fat thermogenesis, a cellular process which converts sugar and fat into heat to help maintain body temperature and support a healthy metabolism
  • Reduce general tiredness and fatigue, support healthy muscle function, and feel good for your age

    Signal contains two ingredients that work synergistically to support metabolic health:

    • Nicotinamide Mononucleotide, NMN (250mg)
      NMN is a highly efficient precursor of the coenzyme nicotinamide adenine dinucleotide (NAD+), which is central to creating cellular energy and performing other key metabolic functions.
    • SIRT3 Activation Complex (150mg)
      Supports healthy mitochondrial function through a combination of honokiol (isolated from the bark of Magnolia officinalis), and viniferin (derived from grapevines). Both honokiol and viniferin are potent activators of SIRT3, a metabolic enzyme found in the mitochondria that helps preserve existing as well as generate new mitochondria.
    • Vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors.
    • NSF Certified for Sport, the only independent third-party certification program recognized by the United States Anti-Doping Agency (USADA). Please confirm the certification of each lot here.
    • See nutrition label for more information.
    • The quality and purity information of every lot is available here.
    • Take two capsules every morning, with or without food.
    • Each bottle contains a 30-day supply.
    • This product is only intended for healthy adults. Do not take if you are pregnant or nursing. Consult with your physician before using.
    Image of Cells and Metabolic Aging

    Your Metabolism Ages Too

    Metabolism converts food into the energy you need for life. As you age, your metabolism slows and becomes less efficient—impacting how quickly and effectively your cells function. 

    This happens for two main reasons: First, levels of a coenzyme called NAD+, which is central to hundreds of metabolic processes and cellular energy production, decline. Second, enzymes inside our mitochondria—the powerhouses of our cells—like SIRT3 that depend on NAD+ to function slow down.

    Illustration of NMN molecule

    How to Target Metabolic Aging in Your Cells

    Signal restores the age-related decline in NAD+ levels with NMN, one of the most efficient precursors of NAD+. A human clinical study demonstrated that 30 days of NMN supplementation at 250mg/day resulted in a 40% increase in NAD+ levels in the blood. NMN supplementation has been shown to support insulin sensitivity, vascular health (critical for athletic endurance), and muscle function.

    See the Science
    Leonard Guarente, Ph.D., Elysium founder, chief scientist, and renowned aging researcher and professor

    “Signal is a novel, mitochondria-centric product formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency.”

    Leonard Guarente, Ph.D., Elysium founder, chief scientist, and renowned aging researcher and professor

    Close-up of a capsule of Signal by Elysium Health

    Activating SIRT3 to Support Mitochondrial Health

    What happens inside your mitochondria is crucial. All your metabolic processes take place here, from energy production and synthesis of cellular building blocks to waste management. The mitochondrial protein SIRT3 drives many of these reactions, as well as protects and generates new mitochondria. The natural ingredients in Signal’s SIRT3 Activation Complex, honokiol and viniferin, are designed to work with NMN to activate SIRT3 to promote mitochondrial health and synthesis, which in turn support metabolic health.

    Signal by Elysium Health Floating on Blue Background
    Signal by Elysium Health Floating on Blue Background

    Elevate your metabolism with a Signal boost.

    Starting from $40/mo

    Why Our Customers Love Signal

    Frequently Asked Questions

    Signal is designed to target metabolic aging at the cellular level by elevating levels of a key metabolite, NAD+, which declines universally with age, and by activating processes involved in supporting mitochondrial health.

    The combination of ingredients in Signal is designed to promote metabolic health, whereas Basis is formulated to target overall cellular aging and DNA maintenance. As metabolic aging is tightly correlated with general aging, there is overlap in the downstream effects of the ingredients in Signal and Basis, and this is reflected in the principal ingredient in both products. As declining NAD+ levels are directly related to general aging and metabolic dysregulation, both Signal and Basis provide an NAD+ precursor molecule to target this decline–Signal contains NMN and Basis contains NR. There is some exciting, early evidence for potential tissue-specificity between the two different NAD+ precursors, as well as varied benefits, suggesting that one precursor may be more dominant in certain tissues than the other. More studies are needed to support this possibility.

    In addition to NAD+ precursors, both products provide ingredients that activate sirtuins–a family of enzymes that play a critical role in aging and metabolism. Signal contains Elysium’s SIRT3 Activation Complex, which activates sirtuin 3 (SIRT3), a sirtuin that resides in mitochondria and has been shown to be involved in maintaining mitochondrial health and the generation of new mitochondria. Basis, on the other hand, contains an ingredient that activates sirtuin 1 (SIRT1). Unlike SIRT3, SIRT1 resides mainly in the nucleus and plays an important role in regulating gene expression and histone modification, pointing to a more complex role for this enzyme in modulating a wide array of processes involved in cellular housekeeping, including DNA maintenance. The SIRT1 activator in Basis has also been shown to exhibit antioxidant properties.

    There is preclinical evidence for potential tissue-specificity as well as varied benefits between the two different NAD+ precursors in Basis and Signal. More research is needed to support these findings, but taking both Basis and Signal may help ensure that NAD+ levels are elevated across a broader range of tissues, and that you’re receiving the benefits offered by each NAD+ precursor. In addition, the secondary ingredients in Signal and Basis target different processes in your cells–Signal activates an enzyme that’s involved in mitochondrial function and biogenesis whereas Basis activates an enzyme that is involved in regulating gene expression. We believe that taking both products can lead to a more comprehensive approach to targeting different aspects of aging that includes cellular and metabolic aging.

    SIRT3 or sirtuin 3 is a member of the sirtuin family of enzymes that depend on NAD+ to function. SIRT3 enzymes reside in mitochondria and play an essential role in maintaining mitochondrial health and metabolic control, including glucose metabolism, cellular energy (ATP) production, fatty acid oxidation, ketone production during fasting, and amino acid cycling. Mitochondria are central hubs for metabolic reactions and produce ~95% of the cell’s energy. As we age, mitochondrial function and levels of mitochondrial sirtuins decline, leading to metabolic dysregulation. Signal is designed to activate SIRT3 and thus promote mitochondrial and metabolic health.

    NMN (nicotinamide mononucleotide) is the immediate precursor to NAD+, an essential coenzyme and key metabolite found in every cell of the human body, and involved in over 500 different cellular reactions. NAD+ is synthesized by the cell through various pathways, some more complex than others. The primary pathway for NAD+ synthesis involves the conversion of nicotinamide (NAM) to NMN and subsequent conversion of NMN to NAD+. As the immediate precursor to NAD+, NMN is a highly efficient precursor, requiring the least amount of steps and energy to convert to NAD+.

    Metabolic aging is the imbalance or dysregulation of our metabolism as a function of aging. As we age, levels of NAD+ decline dramatically. NAD+ is a key metabolite whose levels are closely monitored by the cell in order to tune and balance its metabolic reactions. Regulating the vast number of metabolic reactions to maintain balance or homeostasis between energy production and usage is critical for cell health. In addition to the decline in NAD+ level, the activity and levels of sirtuins (NAD-dependent enzymes involved in regulating metabolism and maintaining energy homeostasis) also decline. The ingredients in Signal are designed to work synergistically to promote metabolic balance and health by elevating NAD+ levels and activating sirtuin 3.

    All of our supplements, Basis, Matter, Format, Signal, and Mosaic, are safe to be taken together. While we have identified no interactions or contraindications to date, if you have questions about a health condition or about making changes to your health routine, we recommend consulting your physician.

    We offer Signal on a month-to-month subscription plan. ​​This plan offers reduced pricing billed monthly at $50 per month and can be canceled prior to your next shipment. Prepaid subscription plans and their discounted pricing are not available for Signal at this time.

    New purchases for prepaid subscription plans and their discounted pricing are not available for Signal for now.

    Any remaining prepaid orders from your existing subscription will continue to ship each month as they normally would. The difference is that it will not renew when it ends. To continue with ongoing deliveries after the remaining prepaid orders are delivered, you may place a new order for month-to-month subscription of Signal.

    Signal is currently available to ship and bill to addresses located in the United States.

    UPS is our shipping partner for standard shipping. Locally, they work with your USPS post office to complete the delivery.