Basis, A New Way To Stay Healthy
With the unprecedented advancement of science and technology, we believe there should be a new way, in addition to diet and exercise, for people to stay healthy.
That’s what Basis is: One product to support the long-term health of your cells.
Cells are the smallest unit of life — and the average human body has trillions of them. In each cell are components called organelles, including familiar names like the mitochondria and the nucleus, which communicate with each other to carry out all of the processes in our body.
This communication consists of physical, chemical, and nutritional processes by which cells convert food to energy, light to imagery, and stimulus to sensation. Research has demonstrated that healthy cellular communication relies on the coenzyme NAD+ and a class of proteins called sirtuins. NAD+ declines in organisms as they age, including in humans, and sirtuins depend on NAD+ to function.
Proteins that act as vital regulators in the cell, turning our genes on and off to control our body’s response to nutrition levels and stress. Sirtuins require NAD+ to function.
Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme found in all living cells. It plays an essential role in hundreds of metabolic processes in the cell. NAD+ powers sirtuins.
Why NAD+ and Sirtuins Are Important
NAD+ and sirtuins are essential to metabolic health. Since sirtuins are dependent on NAD+, their functions often overlap.
The mitochondria turn nutrition into energy by generating ATP, a molecule that transports energy within cells. ATP is the main, and most efficient, energy source for cellular function.
Our DNA is constantly exposed to naturally-occurring factors (e.g., reactive oxygen species or “free radicals”) and external stress (e.g., UVB light), that can harm its structure. When our cells are functioning properly they monitor and correct the mistakes, leading to a more stable genome.
Calcium serves as a messenger with a role in muscle contraction, cell growth, neurotransmission, and other activities.
The liver is central to all metabolic processes in the body, from breaking down fats for energy to modulating the level of blood sugar. These metabolic processes depend on NAD+.
The cell’s – and body’s – memory for, and response to, nutritional and environmental cues, which among other things helps govern our sleep and wake cycle.
Sirtuins use NAD+ in the regulation of gene transcription, which means that they turn genes on and off to control our body’s response to nutrition levels and stress.
Stem Cell Maintenance
Organs depend on stem cells for regular maintenance, so having a healthy number of functioning stem cells is essential to overall well-being.
Sirtuins assume a variety of roles in response to stress to maintain health in the cell. Likewise, NAD+ is essential to a whole category of processes known as oxidation-reduction (redox) reactions, which play a role in converting raw energy, in the form of food, into the type of energy that our body uses: ATP.
Unfolded Protein Response
After being translated from mRNA to a linear chain of amino acids, proteins are folded into a three-dimensional shape that corresponds with their function. Proteins that aren’t properly assembled are destroyed before they ever leave the cell.
Basis Increases NAD+ Levels With Two Compounds
Basis contains two unique compounds found in nature: nicotinamide riboside (NR), a precursor to NAD+, and pterostilbene, a polyphenol. Both have been validated in numerous scientific studies over the past two decades.
Clinical research demonstrates that Nicotinamide Riboside (NR), which is found in trace amounts in milk, is a highly efficient precursor to NAD+. Incorporating NR into the body has been shown to restore NAD+ levels in laboratory models, combating age-related decline in the NAD+ supply that cells experience. Preclinical studies link the restoration of NAD+ supplies to an improvement in metabolic efficiency and overall health.
Pterostilbene is a powerful polyphenol created by plants to protect against internal and external stress. It is available in the human diet only in trace amounts, in certain types of berries. Pterostilbene is more bioavailable than other plant-derived compounds in the same family, meaning that it’s more readily absorbed by the body, and lab studies have shown that it may improve metabolic health, in particular by activating sirtuins.
The Science Behind Basis
There is a wide body of scientific literature about the two ingredients in Basis, nicotinamide riboside and pterostilbene, as well as its biological targets, the coenzyme NAD+ and sirtuin proteins. These studies represent a portion of that research.