You just took Basis—nothing could be happening yet, right? Actually, the nicotinamide riboside is already making big moves. It enters your cells via equilibrative nucleoside transporters, membrane proteins that shuttle molecules across.

*Individual results may vary. This timeline may differ from the typical purchaser’s experience and is not intended to represent or guarantee that anyone will receive the same or similar results.

NAD+ levels are already on the rise at the cellular level. You can expect support for increased cellular energy, improved mitochondrial function, housekeeping for your proteome and genome, and cellular protection from everyday stressors (for example, oxidative stress). Not bad for a day’s work.

NAD+ levels continue to rise in your cells and throughout your body. Keep doing what you’re doing while Basis works in the background.

Now results are really adding up. If you had all the gear for NAD+ analysis from whole-blood lysate, you could see for yourself. (Instead, you can read our scientific paper.) Your cellular NAD+ levels are now 40% higher than they were on day one, and that’s where they’ll stay if you keep taking Basis. Where is all this NAD+ going? Studies suggest that NR supplementation increases NAD+ and affects NAD+-related metabolites in multiple tissues at 30 days—including your muscle and brain.

You’ve logged 30 days of elevated and sustained NAD+ levels in your cells and tissues. That’s a big deal because 330 billion cells turn over each day. Colon epithelial cells, for example, turn over in 3-5 days while the upper layer of the skin, or the epidermis, takes roughly 39 days to regenerate. NAD+ can help with supporting these processes and tissue health. In your skin, more NAD+ can support the process of synthesizing ceramide and collagen. Our first human clinical trial on Basis also showed preliminary evidence for supporting liver health and results from our latest, 6-month, human clinical study (published in Hepatology) confirmed these initial findings in healthy adults with non-alcoholic fatty liver.

A lot happens in six months. What’s changed in your life? With Basis, it’s all starting to add up—to systemic health benefits. Basis is supporting multiple tissues and systems, in a sustained manner. For example, one study showed that six months of increased NAD+ levels reduced transepidermal water loss—a measure of overall skin health and barrier function.

Congratulations on your first year. NAD+ declines by as much as 50% every 20 years, according to research. But human studies are beginning to show an association between NAD+ abundance and healthy aging status. Keep taking Basis to counteract the age-related decline of NAD+ and to build on a year’s worth of benefits. Just like with exercise, sleep, and diet—consistency is key.