The immunology of aging
Immunity is not the only function impacted by an aging immune system. Immune cells pervade every organ and influence all bodily functions, and preclinical studies suggest that the aging immune system may even be a key contributor to the aging of our organs. Put simply, it’s impossible to overstate the importance of our immune system
As we age, the balance of immune cells shift toward pro-inflammatory cell types, including senescent immune cells that cease to replicate and secrete inflammatory molecules. All cell types in the body can become senescent (usually in response to cellular damage) and secrete inflammatory molecules. With aging, the immune cells—which normally home in on, and clear these senescent cells—become senescent themselves, and the mechanism breaks down. Not only do senescent immune cells fail to clean up senescent cells, they secrete their own inflammatory molecules, adding to the inflammation surrounding healthy tissue. This phenomenon is known as “inflammaging” and can accelerate the aging process. Inflammaging is one of the 12 hallmarks of aging [1].

A comprehensive approach to immune aging
Format, by Elysium Health, is designed to combat immune aging with three parallel approaches: foundational immunity nutrients serve to protect and support healthy immune cells, while the Inflammaging Complex targets age-related inflammation, and the powerful, intermittent Senolytic Complex helps to clear the body of senescent cells (a major source of inflammaging).
1. Protect and support healthy immune cells
Foundational immunity ingredients, vitamin C, selenium, and zinc, protect immune cells from damaging free radicals and oxidative stress to support and maintain a healthy immune system. Format provides 100% of your daily vitamin C.
2. Combat inflammaging
Inflammaging involves elevated inflammatory markers like IL-6, CRP, and TNF-ɑ. Format’s patented tamarind-turmeric blend in the Inflammaging Complex has been clinically proven to reduce these markers in joint conditions and lessen knee discomfort after exercise [2-4]. The Complex also includes broccoli extract (a sulforaphane source), which further promotes a healthy inflammatory status [5].

Chart 1. Supplementation with the tamarind and turmeric extract blend in Elysium’s Inflammaging Complex resulted in a significant decrease in circulating CRP levels in the serum compared to placebo and baseline. *P < 0.05. Adapted from Kare et al., 2022.
3. Target inflammaging at its source with senolytics
Based on cutting-edge research in cell senescence, the Senolytic Complex is proven to clear senescent cells in human cell lines. It contains potent senolytics, proven to clear senescent cells, boost muscle recovery and endurance, and support cellular rejuvenation [6-8]. Taken monthly, this “hit-and-run” approach aids in reducing the body’s burden of senescent cells.

Chart 2. Senescent human fibroblasts (IMR90) and endothelial cells (HUVEC) were treated with Elysium’s Senolytic Complex and evaluated 48 hrs after treatment. A significant reduction in senescent cells, in both cell lines, was observed compared to vehicle-treated control (*P<0.05).
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References:
1. Lopez-Otin, C. et al., Cell. 186(2):243-278 (2023)
2. Kare, S.K. et al., Evid Based Complement Alternat Med. 2022:2226139 (2022)
3. Prasad, N. et al., Food Nutr Res. 67 (2023)
4. Rao, P.S. et al., Int J Med Sci. 16(6):845-853 (2019)
5. López-Chillón, M.T. et al., Clin Nutr. 38(2):745-752 (2019)
6. Chaib, S. et al., Nat Med. 28, 1556–1568 (2022).
7. Wu, J. et al., J Ginseng Res. 43(4):580-588 (2019)
8. Wu, J. et al., Journal of Functional Foods. 58:27-33 (2019)