Signal journey

Boost your NAD+ for a whole year with Signal. Here’s what you might expect, according to the science.

SPOILER: ELEVATED NAD+ LEVELS ARE A GOOD THING.

Like fast results? It only takes one hour after your first dose of Signal to begin providing the metabolic support your cells need. From there, you can expect to unlock evidence-based benefits from your cells to whole body systems: increased NAD+, healthy mitochondria, muscle benefits, and more.

Start Your Journey

Boost your NAD+ for a whole year with Signal. Here’s what you might expect, according to the science.

SPOILER: ELEVATED NAD+ LEVELS ARE A GOOD THING.

Like fast results? It only takes one hour after your first dose of Signal to begin providing the metabolic support your cells need. From there, you can expect to unlock evidence-based benefits from your cells to whole body systems: increased NAD+, healthy mitochondria, muscle benefits, and more.

Start Your Journey

Boost your NAD+ for a whole year with Signal. Here’s what you might expect, according to the science.

SPOILER: ELEVATED NAD+ LEVELS ARE A GOOD THING.

Like fast results? It only takes one hour after your first dose of Signal to begin providing the metabolic support your cells need. From there, you can expect to unlock evidence-based benefits from your cells to whole body systems: increased NAD+, healthy mitochondria, muscle benefits, and more.

Start Your Journey

HOUR 1

NMN enters your cells

NMN acts quickly, according to the research. Preclinical studies in mice on the pharmacokinetics of NMN suggest that it’s absorbed from the gut into blood circulation within minutes and transported into tissues between 10 and 30 minutes [1, 2]. That’s when the magic (or biochemistry) happens.

The NMN is immediately utilized for NAD+ biosynthesis. Research suggests that fast uptake is made possible by an NMN-specific transporter called Slc12a8. A study published in Nature Metabolism identified the transporter, which is especially concentrated in the small intestine in mice [3].

5 HOURS

NAD+ is on the rise

Same day, more activity in your cells. Studies in humans show increased levels of NAD+ metabolites in blood plasma within the first few hours of NMN supplementation—and they continue to rise steadily, suggesting increased utilization of NAD+ in cells and tissues [4].

Your cells are already taking advantage of increased NAD+ levels to support hundreds of critical cellular processes. If you listen closely, you may hear them say, “thank you.”

DAY 3

Happy mitochondria

Your NAD+ levels continue to rise, now benefiting your cell’s powerhouses and the place where your cellular energy is made: the mitochondria. A preclinical study demonstrated that treatment of human kidney cells in culture with NMN for three days resulted in increased mitochondrial replication [5].

In addition to NMN, Signal contains honokiol and viniferin, potent activators of SIRT3—a mitochondrial enzyme and member of the sirtuin family—further supporting your mitochondrial health and function. Viniferin has been shown in preclinical studies to promote new mitochondrial synthesis [6].

DAY 30

Up to 40 % increase in NAD+

The data is in: At one month, blood NAD+ levels are now up to 40% higher than they were when you took your first two capsules. That’s where they’ll stay if you keep taking Signal, based on a human clinical study that examined NMN supplementation at a dose of 250 mg of NMN per day in healthy adults [7].

Keep scrolling to read additional time points.

HOUR 1

NMN enters your cells

NMN acts quickly, according to the research. Preclinical studies in mice on the pharmacokinetics of NMN suggest that it’s absorbed from the gut into blood circulation within minutes and transported into tissues between 10 and 30 minutes [1, 2]. That’s when the magic (or biochemistry) happens.

The NMN is immediately utilized for NAD+ biosynthesis. Research suggests that fast uptake is made possible by an NMN-specific transporter called Slc12a8. A study published in Nature Metabolism identified the transporter, which is especially concentrated in the small intestine in mice [3].

5 HOURS

NAD+ is on the rise

Same day, more activity in your cells. Studies in humans show increased levels of NAD+ metabolites in blood plasma within the first few hours of NMN supplementation—and they continue to rise steadily, suggesting increased utilization of NAD+ in cells and tissues [4].

Your cells are already taking advantage of increased NAD+ levels to support hundreds of critical cellular processes. If you listen closely, you may hear them say, “thank you.”

DAY 3

Happy mitochondria

Your NAD+ levels continue to rise, now benefiting your cell’s powerhouses and the place where your cellular energy is made: the mitochondria. A preclinical study demonstrated that treatment of human kidney cells in culture with NMN for three days resulted in increased mitochondrial replication [5].

In addition to NMN, Signal contains honokiol and viniferin, potent activators of SIRT3—a mitochondrial enzyme and member of the sirtuin family—further supporting your mitochondrial health and function. Viniferin has been shown in preclinical studies to promote new mitochondrial synthesis [6].

DAY 30

Up to 40% increase in NAD+

The data is in: At one month, blood NAD+ levels are now up to 40% higher than they were when you took your first two capsules. That’s where they’ll stay if you keep taking Signal, based on a human clinical study that examined NMN supplementation at a dose of 250 mg of NMN per day in healthy adults [7].

Keep scrolling for additional timepoints.

Signal customers share their reviews.

✓ Verified buyer

“I have been taking Signal for about 6 weeks and I have noticed I have more energy and therefore more desire to be busy and active. It works well for me and I will stay with it.”

Mary
Age: 60-69

✓ Verified buyer

“I am a 77 yr old who loves cycling and l'm riding 4 or 5 times per week, aiming for 6000+ miles this year. Began using Signal along with Basis to keep my energy level up. After several months, l think l note faster recovery times and generally a boost in day-to-day energy levels- especially chasing my 2 young grandsons!”

Perry E.
Age: 70+

✓ Verified buyer

“My goal is to manage my aging process as best that I can towards a robust quality of life. I believe that Signal helps that at a cellular level as epigenetic measurements seem to support that I am achieving my goal. I recommend taking Signal as a key part of an overall program to age well.”

Kathleen K.
Age: 60-69

Signal customers share their reviews.

✓ Verified buyer

“I have been taking Signal for about 6 weeks and I have noticed I have more energy and therefore more desire to be busy and active. It works well for me and I will stay with it.”

Mary
Age: 60-69

✓ Verified buyer

“I am a 77 yr old who loves cycling and l'm riding 4 or 5 times per week, aiming for 6000+ miles this year. Began using Signal along with Basis to keep my energy level up. After several months, l think l note faster recovery times and generally a boost in day-to-day energy levels- especially chasing my 2 young grandsons!”

Perry E.
Age: 70+

✓ Verified buyer

“My goal is to manage my aging process as best that I can towards a robust quality of life. I believe that Signal helps that at a cellular level as epigenetic measurements seem to support that I am achieving my goal. I recommend taking Signal as a key part of an overall program to age well.”

Kathleen K.
Age: 60-69

HOUR 1

NMN enters your cells

NMN acts quickly, according to the research. Preclinical studies in mice on the pharmacokinetics of NMN suggest that it’s absorbed from the gut into blood circulation within minutes and transported into tissues between 10 and 30 minutes [1, 2]. That’s when the magic (or biochemistry) happens.

The NMN is immediately utilized for NAD+ biosynthesis. Research suggests that fast uptake is made possible by an NMN-specific transporter called Slc12a8. A study published in Nature Metabolism identified the transporter, which is especially concentrated in the small intestine in mice [3].

5 HOURS

NAD+ is on the rise

Same day, more activity in your cells. Studies in humans show increased levels of NAD+ metabolites in blood plasma within the first few hours of NMN supplementation—and they continue to rise steadily, suggesting increased utilization of NAD+ in cells and tissues [4].

Your cells are already taking advantage of increased NAD+ levels to support hundreds of critical cellular processes. If you listen closely, you may hear them say, “thank you.”

DAY 3

Happy mitochondria

Your NAD+ levels continue to rise, now benefiting your cell’s powerhouses and the place where your cellular energy is made: the mitochondria. A preclinical study demonstrated that treatment of human kidney cells in culture with NMN for three days resulted in increased mitochondrial replication [5].

In addition to NMN, Signal contains honokiol and viniferin, potent activators of SIRT3—a mitochondrial enzyme and member of the sirtuin family—further supporting your mitochondrial health and function. Viniferin has been shown in preclinical studies to promote new mitochondrial synthesis [6].

DAY 30

Up to 40% increase in NAD+

The data is in: At one month, blood NAD+ levels are now up to 40% higher than they were when you took your first two capsules. That’s where they’ll stay if you keep taking Signal, based on a human clinical study that examined NMN supplementation at a dose of 250 mg of NMN per day in healthy adults [7].

Keep scrolling to read additional timepoints.

Signal customers share their reviews.

✓ Verified buyer

“I have been taking Signal for about 6 weeks and I have noticed I have more energy and therefore more desire to be busy and active. It works well for me and I will stay with it.”

Mary
Age: 60-69

✓ Verified buyer

“I am a 77 yr old who loves cycling and l'm riding 4 or 5 times per week, aiming for 6000+ miles this year. Began using Signal along with Basis to keep my energy level up. After several months, l think l note faster recovery times and generally a boost in day-to-day energy levels- especially chasing my 2 young grandsons!”

Perry E.
Age: 70+

✓ Verified buyer

“My goal is to manage my aging process as best that I can towards a robust quality of life. I believe that Signal helps that at a cellular level as epigenetic measurements seem to support that I am achieving my goal. I recommend taking Signal as a key part of an overall program to age well.”

Kathleen K.
Age: 60-69

6 WEEKS

Muscle benefits

We’re moving from cells to systems as aspects of your fitness may be improving. A human clinical study published in Nature Aging demonstrated NAD+ was one of the most depleted metabolites in aging muscle and that high levels of NAD+ were associated with healthy muscle function [8]. Another clinical study found that oral supplementation of NMN at a dose of 250 mg per day for 6 weeks partly improved muscle strength and performance in healthy older men [9].

8 WEEKS

Surface-level benefits

How’s your skin looking? Advanced glycation end products, or AGEs, are markers of skin aging. A small clinical trial involving healthy postmenopausal women found that NMN supplementation for eight weeks at 300 mg of NMN per day resulted in decreased AGEs in the skin [10].

10 WEEKS

Healthy insulin sensitivity

There may be more happening in your muscles at 10 weeks. One clinical study of prediabetic women made two important discoveries. The first was an increase in NMN metabolites in skeletal muscle tissue, suggesting that the muscles were using more NAD+. The second finding suggested that NMN may support healthy insulin sensitivity in skeletal muscle and helps regulate the expression of genes related to muscle remodeling—the turnover of muscle proteins, organelles, and cell populations. Participants in the trial were supplemented with 250 mg of NMN per day [11].

3 MONTHS

Faster walking and longer telomeres

It’s been three months and you’ve logged 60 days of 40% higher levels of NAD+ in your cells and tissues. What do you have to show for it? A lot, according to clinical studies. One trial found an improvement in gait speed (translation: walking speed) in healthy, elderly men who took 250 mg of NMN per day [9]. The other found that telomere length had doubled in peripheral blood mononuclear cells at a dose of 300 mg of NMN per day [12].

6 MONTHS

It's all starting to add up

A lot happens in six months. What’s changed in your life? With Signal, it’s all starting to add up to systemic health benefits. Signal is supporting multiple tissues and systems, in a sustained manner, by targeting metabolic aging where it matters—in your cells.

1 YEAR

Healthy aging and NAD+ go hand-in-hand

Congratulations on your first year of replenishing the NAD+ lost to aging. NAD+ declines by as much as 50% every 20 years, according to research. It’s important to keep up your Signal routine: Research shows that four weeks after discontinuation of NMN, NAD+ levels returned to pre-supplementation levels [7]. Just like with exercise, sleep, and diet—consistency is key for long-term results. Human studies are beginning to show that healthy aging and NAD+ abundance go hand-in-hand [8]. Let Signal help you feel good for your age.

Disclaimer
Individual results may vary. This timeline may be different from the typical purchaser’s experience, and is not intended to represent or guarantee that anyone will receive the same or similar results.

6 WEEKS

Muscle benefits

We’re moving from cells to systems as aspects of your fitness may be improving. A human clinical study published in Nature Aging demonstrated NAD+ was one of the most depleted metabolites in aging muscle and that high levels of NAD+ were associated with healthy muscle function [8].

Another clinical study found that oral supplementation of NMN at a dose of 250 mg per day for 6 weeks partly improved muscle strength and performance in healthy older men [9].

8 WEEKS

Surface-level benefits

How’s your skin looking? Advanced glycation end products, or AGEs, are markers of skin aging. A small clinical trial involving healthy postmenopausal women found that NMN supplementation for eight weeks at 300 mg of NMN per day resulted in decreased AGEs in the skin [10].

10 WEEKS

Healthy insulin sensitivity

There may be more happening in your muscles at 10 weeks. One clinical study of prediabetic women made two important discoveries. The first was an increase in NMN metabolites in skeletal muscle tissue, suggesting that the muscles were using more NAD+. The second finding suggested that NMN may support healthy insulin sensitivity in skeletal muscle and helps regulate the expression of genes related to muscle remodeling—the turnover of muscle proteins, organelles, and cell populations. Participants in the trial were supplemented with 250 mg of NMN per day [11].

3 MONTHS

Faster walking and longer telomeres

It’s been three months and you’ve logged 60 days of 40% higher levels of NAD+ in your cells and tissues. What do you have to show for it? A lot, according to clinical studies. One trial found an improvement in gait speed (translation: walking speed) in healthy, elderly men who took 250 mg of NMN per day [9]. The other found that telomere length had doubled in peripheral blood mononuclear cells at a dose of 300 mg of NMN per day [12].

6 MONTHS

It's all starting to add up

A lot happens in six months. What’s changed in your life? With Signal, it’s all starting to add up to systemic health benefits. Signal is supporting multiple tissues and systems, in a sustained manner, by targeting metabolic aging where it matters—in your cells.

1 YEAR

Healthy aging and NAD+ go hand-in-hand

Congratulations on your first year of replenishing the NAD+ lost to aging. NAD+ declines by as much as 50% every 20 years, according to research. It’s important to keep up your Signal routine: Research shows that four weeks after discontinuation of NMN, NAD+ levels returned to pre-supplementation levels [7]. Just like with exercise, sleep, and diet—consistency is key for long-term results. Human studies are beginning to show that healthy aging and NAD+ abundance go hand-in-hand [8]. Let Signal help you feel good for your age.

Disclaimer
Individual results may vary. This timeline may be different from the typical purchaser’s experience, and is not intended to represent or guarantee that anyone will receive the same or similar results.

6 WEEKS

Muscle benefits

We’re moving from cells to systems as aspects of your fitness may be improving. A human clinical study published in Nature Aging demonstrated NAD+ was one of the most depleted metabolites in aging muscle and that high levels of NAD+ were associated with healthy muscle function [8].

Another clinical study found that oral supplementation of NMN at a dose of 250 mg per day for 6 weeks partly improved muscle strength and performance in healthy older men [9].

8 WEEKS

Surface-level benefits

How’s your skin looking? Advanced glycation end products, or AGEs, are markers of skin aging. A small clinical trial involving healthy postmenopausal women found that NMN supplementation for eight weeks at 300 mg of NMN per day resulted in decreased AGEs in the skin [10].

10 WEEKS

Healthy insulin sensitivity

There may be more happening in your muscles at 10 weeks. One clinical study of prediabetic women made two important discoveries. The first was an increase in NMN metabolites in skeletal muscle tissue, suggesting that the muscles were using more NAD+. The second finding suggested that NMN may support healthy insulin sensitivity in skeletal muscle and helps regulate the expression of genes related to muscle remodeling—the turnover of muscle proteins, organelles, and cell populations. Participants in the trial were supplemented with 250 mg of NMN per day [11].

3 MONTHS

Faster walking and longer telomeres

It’s been three months and you’ve logged 60 days of 40% higher levels of NAD+ in your cells and tissues. What do you have to show for it? A lot, according to clinical studies. One trial found an improvement in gait speed (translation: walking speed) in healthy, elderly men who took 250 mg of NMN per day [9]. The other found that telomere length had doubled in peripheral blood mononuclear cells at a dose of 300 mg of NMN per day [12].

6 MONTHS

It's all starting to add up

A lot happens in six months. What’s changed in your life? With Signal, it’s all starting to add up to systemic health benefits. Signal is supporting multiple tissues and systems, in a sustained manner, by targeting metabolic aging where it matters—in your cells.

1 YEAR

Healthy aging and NAD+ go hand-in-hand

Congratulations on your first year of replenishing the NAD+ lost to aging. NAD+ declines by as much as 50% every 20 years, according to research. It’s important to keep up your Signal routine: Research shows that four weeks after discontinuation of NMN, NAD+ levels returned to pre-supplementation levels [7]. Just like with exercise, sleep, and diet—consistency is key for long-term results. Human studies are beginning to show that healthy aging and NAD+ abundance go hand-in-hand [8]. Let Signal help you feel good for your age.

Disclaimer
Individual results may vary. This timeline may be different from the typical purchaser’s experience, and is not intended to represent or guarantee that anyone will receive the same or similar results.

“Signal is a novel, mitochondria-centric product formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency.”

- Leonard Guarente, Ph.D., Elysium Co-founder and Chief Scientist

“Signal is a novel, mitochondria-centric product formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency.”

- Leonard Guarente, Ph.D., Elysium Co-founder and Chief Scientist

“Signal is a novel, mitochondria-centric product formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency.”

- Leonard Guarente, Ph.D., Elysium Co-founder and Chief Scientist

Metabolic Aging

Signal

Get 25% OFF a monthly subscription + Free Shipping with code TRY25

Power up the powerhouse of your cells. Signal is designed to target metabolic aging by protecting mitochondria—where the energy in your cells is made. Increase NAD+ through the precursor NMN to protect and help generate new mitochondria and help your cells remain nimble to daily metabolic changes as you age.

Increase levels of the critical coenzyme NAD+ by 40% via the highly efficient precursor NMN

Activate sirtuin 3 (SIRT3) to protect and generate new mitochondria to support cellular metabolism and energy

Help maintain healthy insulin sensitivity in muscle—essential to maintaining blood sugar levels

Support vascular health—critical for your athletic endurance

Support brown fat thermogenesis, a cellular process which converts sugar and fat into heat to help maintain body temperature and support a healthy metabolism

Reduces general tiredness and fatigue, supports healthy muscle function, helps you feel good for your age

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[1] Yoshino, J., et al., Cell Metab. 14: 528–536 (2011).

[2] Mills, K. F. et al. Cell Metab. 24: 795–806 (2016).

[3] Grozio, A., et al., Nature Metabolism 1: 47-57 (2019).

[4] Irie, J., et al., Endocrine Journal 67 (2): 153-160 (2020).

[5] Nomiyama, T., et al., The Journal of Biochemistry 171 (3): 325-338 (2021).

[6] Fu, J., et al., J Biol Chem. 287 (29): 24460–24472 (2012).

[7] Okabe, K., et al., Frontiers in Nutrition 9: 868640 (2022).

[8] Janssens, G.E. et al., Nat Aging 2: 254–263 (2022).

[9] Igarashi, M. et al., NPG Aging 8: 5 (2022).

[10] Morita, Y. et al., Glycative Stress Research 9 (2): 33-41 (2022).

[11] Yoshino, M. et al., Science 372 (6547): 1224-1229 (2021).

[12] Niu, K-M. et al., Frontiers in Nutrition 8: 756243 (2021).

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to screen, diagnose, treat, cure, or prevent any disease or condition or assess risk of any disease or condition.

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