NAD+ Supplement for Cellular Aging

per bottle

Select a subscription option

Select a subscription duration

Select Arrow icon
Minus icon Plus icon

Free Shipping • Prepay to Save •  Pause Anytime

Target aging at the source—your cells. Increase your NAD+ levels with Basis for healthy aging, to boost cellular energy, and maintain healthy DNA. Developed by Elysium chief scientist and renowned aging researcher Leonard Guarente, Ph.D. Increase and sustain NAD+ levels by 40% to:

  • Promote healthy aging, feel good for your age
  • Promote cellular energy and reduce general tiredness and fatigue
  • Fight aging at the cellular level and protect your DNA from stressors
  • Support collagen and ceramide synthesis for healthy skin
  • Support healthy muscle function

Basis contains two powerful ingredients to combat cellular aging:

  • Nicotinamide Riboside (NR-E)

    NR is a naturally occurring form of vitamin B3 and a highly efficient precursor to NAD+—the raw material that the body uses to make NAD+ via a two-step process. This precursor has been shown to preferentially elevate NAD+ compared to nicotinic acid and nicotinamide, also called niacin.
  • Pterostilbene (PT)

    A powerful polyphenol naturally produced by plants to protect against internal and external stress. The potent combination of NR and pterostilbene in Basis is designed to increase NAD+ levels and counter the decrease in the activity of sirtuins, which occurs with normal aging.
  • Vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors.
  • NSF Certified for Sport, the only independent third-party certification program recognized by the United States Anti-Doping Agency (USADA). Please confirm the certification of each lot here.
  • See nutrition label for more information.
  • The quality and purity information of every lot is available here.
  • Take two capsules in the morning, with or without food.
  • Each bottle contains a 30-day supply.
  • This product is only intended for healthy adults. Do not take if you are pregnant or nursing. Consult with your physician before using.

NAD+ Levels and Healthy Aging go Hand-in-Hand

Research published in Nature Aging “suggests that a clear association exists between NAD+ and health status in human aging.” NAD+ (nicotinamide adenine dinucleotide) is found in every cell in your body. It is essential to the chemistry that keeps you up and running.

Unfortunately, NAD+ levels decline universally as we age.

How can you increase your NAD+ levels? Basis is the evidence-based choice

We now have a way to safely and sustainably boost NAD+ levels. Developed by Dr. Leonard Guarente, a leader in the field of aging research, Basis was clinically proven to increase NAD+ levels by an average of 40% in a double-blind, randomized, placebo-controlled clinical trial published in the peer-reviewed journal Nature Partner Journals: Aging and Mechanisms of Disease

Boosted NAD+ activates sirtuins, supports cellular energy and metabolism, targets cellular aging to promote a healthy cellular aging process, and helps maintain healthy DNA.

See the Science
Leonard Guarente, Ph.D., Elysium Co-founder and Chief Scientist

“I believe Basis is a product that can improve cellular health and target, at least, some of the deficits incurred by aging. It is an important part of a strategy that I follow, along with exercise and a healthy diet, to maintain an active life as I enter my seventies, and hopefully much longer.”

Leonard Guarente, Ph.D., Elysium Co-founder and Chief Scientist

Why is Basis unique among NAD+ supplements?

Basis is clinically proven to safely and sustainably increase NAD+ by an average of 40% in humans. Elysium’s toxicology study also confirmed the superiority of the NR-E in Basis when compared to the published safety profiles of other NAD+ supplements, underscoring the company’s rigorous commitment to research and quality. 

The synergistic combination of Elysium’s proprietary and high-purity nicotinamide riboside (NR-E) with potent antioxidant pterostilbene (PT) makes Basis extraordinarily effective. Basis is also third-party tested by independent labs both during and after manufacture for purity and quality, and is independently verified as NSF Certified for Sport.

Live your best life with healthy cells.

Starting from $40/mo

Start Your Basis Journey

Here's what happens when you take Basis, from four hours to the one-year mark.*

Hour 4

You just took Basis—nothing could be happening yet, right? Actually, the nicotinamide riboside is already making big moves. It enters your cells via equilibrative nucleoside transporters, membrane proteins that shuttle molecules across.

*Individual results may vary. This timeline may differ from the typical purchaser’s experience and is not intended to represent or guarantee that anyone will receive the same or similar results.

Day 01

NAD+ levels are already on the rise at the cellular level. You can expect support for increased cellular energy, improved mitochondrial function, housekeeping for your proteome and genome, and cellular protection from everyday stressors (for example, oxidative stress). Not bad for a day’s work.

Day 14

NAD+ levels continue to rise in your cells and throughout your body. Keep doing what you’re doing while Basis works in the background.

Day 30

Now results are really adding up. If you had all the gear for NAD+ analysis from whole-blood lysate, you could see for yourself. (Instead, you can read our scientific paper.) Your cellular NAD+ levels are now 40% higher than they were on day one, and that’s where they’ll stay if you keep taking Basis. Where is all this NAD+ going? Studies suggest that NR supplementation increases NAD+ and affects NAD+-related metabolites in multiple tissues at 30 days—including your muscle and brain.

Day 60

You’ve logged 30 days of elevated and sustained NAD+ levels in your cells and tissues. That’s a big deal because 330 billion cells turn over each day. Colon epithelial cells, for example, turn over in 3-5 days while the upper layer of the skin, or the epidermis, takes roughly 39 days to regenerate. NAD+ can help with supporting these processes and tissue health. In your skin, more NAD+ can support the process of synthesizing ceramide and collagen. Our first human clinical trial on Basis also showed preliminary evidence for supporting liver health and results from our latest, 6-month, human clinical study (published in Hepatology) confirmed these initial findings in healthy adults with non-alcoholic fatty liver.

Day 180

A lot happens in six months. What’s changed in your life? With Basis, it’s all starting to add up—to systemic health benefits. Basis is supporting multiple tissues and systems, in a sustained manner. For example, one study showed that six months of increased NAD+ levels reduced transepidermal water loss—a measure of overall skin health and barrier function.

Day 365

Congratulations on your first year. NAD+ declines by as much as 50% every 20 years, according to research. But human studies are beginning to show an association between NAD+ abundance and healthy aging status. Keep taking Basis to counteract the age-related decline of NAD+ and to build on a year’s worth of benefits. Just like with exercise, sleep, and diet—consistency is key.

Basis: The Supplement Experts Take

Church, Ph.D

Professor of Genetics, Harvard Medical School and MIT

Church, Ph.D

“In my lab, we are constantly asking, 'What's the utility of this pure science that we're doing? Let's nudge it a little bit in a direction where people can connect to it and, hopefully, help them in some way.' Basis is the result of this kind of thinking - decades of research focused on the importance of sirtuins and NAD+ that led to a product that people can use in their everyday lives to support their cellular health.”

Kirsty Godso

Nike Master Trainer, Performance Specialist at Elysium Health

“I believe in keeping things ultra simple. One of my go-to ways to invest in myself is keeping my body’s cells in top shape. I take the NAD+ booster Basis—created by an MIT scientist—to optimize cellular metabolism and cellular energy.”

Levine, Ph.D.

Yale Center for Research on Aging (Y-Age)

“As a scientist who studies the biological aging process, I feel lucky to have a front-row seat to the amazing discoveries coming out of this field. As such, I make every attempt to apply what my colleagues and I are learning in the lab to what I do in my everyday life. In addition to following a specific dietary plan, practicing fasting, engaging in high intensity exercise, and trying to get 7.5 hours of sleep per night, I am also a proud user of Basis. In fact, it is the only supplement I currently use.”

Why Our Customers Love Basis

Frequently Asked Questions

Sirtuins are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. However, sirtuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells.

NAD+, or nicotinamide adenine dinucleotide, is a critical coenzyme found in every cell in your body, and it’s involved in hundreds of metabolic processes — but NAD+ levels decline with age. NAD+ has two general sets of reactions in the human body: Helping turn nutrients into cellular energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions. These processes are incredibly important.

This form of Vitamin B could be the key to increasing NAD+ levels — here’s why. Nicotinamide riboside is often called NR for short, and it’s a precursor to NAD+, meaning it's the raw material from which your body makes NAD+ through a series of chemical transformations. Human clinical studies, including ours, have shown efficacy of NR supplementation in increasing NAD+ levels.

Pterostilbene is a polyphenol, a type of molecule that occurs in plants, particularly small berries and nuts. Blueberries are a particularly rich source of pterostilbene; although it is found in grapes, pterostilbene (unlike its cousin resveratrol) doesn’t survive the wine-making process.

“Phenol” refers to a certain chemical structure (in this case, a hydroxyl group linked to a benzene ring); “poly” just means the molecules have more than one of the structure. One of polyphenols’ main jobs is to help the plant fight off pathogens. When eaten by humans, polyphenols may serve as powerful antioxidants.

Basis is designed to work beneath the surface, so its primary purpose is not to deliver surface-level results. Taking Basis is an investment in the long-term health of your cells, and you may not feel different despite the improvements happening inside your body. Everyone’s physiology is unique and results vary from person to person.

Elysium conducted a first-in-humans study demonstrating clearly that Basis can increase and sustain cellular NAD+ levels. Participants in the trial experienced a 40% average increase in cellular NAD+ levels within a month, which was maintained for the duration of the trial. We also tested a variety of biological markers to add to the existing body of evidence confirming that the ingredients in Basis are safe.

Our prepaid subscription plans are our most cost-effective options. When you select a semi-annual or annual plan, the pricing offers a savings to customers who commit to a long-term subscription. The longer the commitment, the greater the savings: $40/bottle for a 1-year (annual) subscription and $45/bottle for a 6-month (semi-annual) subscription. These prepaid subscriptions are considered final sale, so if you cancel in the middle of a 6-month or 1-year plan, you will continue to receive the remaining bottles, and the cancellation will take effect at the end of your plan before renewal. Our monthly subscriptions are $50/month and can be canceled at any time prior to your next shipment. You can also place a single-purchase order by selecting “Individual Purchase” on the checkout page for $60. Please contact our Customer Experience Team at if you need to talk about your plan.

Basis is available in the United States and Canada. Matter, Format, and Index, are currently only available to ship and bill to addresses located in the U.S. Sign up for our newsletter to be notified of updates related to the international availability of our products.

DHL is our shipping partner. Locally, they work with your USPS post office to complete the delivery.

All Elysium products can be purchased directly through our website and are not currently available in any retail stores. Basis is available for purchase to addresses that bill and ship in the United States and Canada, and Matter, Format, and Index are available for purchase in the U.S. To stay up to date on the international availability of our products, please subscribe to our newsletter.